Centenarians' Blood Tests Point to Unique Biological Factors Contributing to Long Life
News Article: Blood Biomarker Profiles Linked to Exceptional Longevity
A groundbreaking study conducted by the Swedish AMORIS cohort has identified blood biomarker profiles associated with exceptional longevity, specifically living to the age of 100 years [1][3]. While the exact biomarkers identified in the study are not explicitly listed in the provided search results, the research focuses on differences in blood biomarker levels that increase the likelihood of reaching a century.
The study found that centenarians rarely displayed extremely high or low values for biomarkers such as glucose and creatinine, suggesting that maintaining kidney and liver values, glucose, and uric acid levels could be beneficial for exceptional longevity [2]. Interestingly, for most biomarkers, the median values didn't differ significantly between centenarians and non-centenarians.
One notable finding was the association between uric acid levels and longevity. People in the group with the lowest uric acid had a 4% chance of reaching 100, while only 1.5% of the group with the highest uric acid levels made it to age 100 [4]. To lower uric acid levels, reducing the consumption of red meat, seafood, alcohol, and sugary sodas is recommended [5]. Foods that help reduce uric acid include almonds and the DASH diet.
The study included 12 blood-based biomarkers related to inflammation, metabolism, liver and kidney function, potential malnutrition, and anemia [6]. The researchers investigated biomarkers associated with nutrition, such as albumin, creatinine (linked to kidney function), and iron and total iron-binding capacity (TIBC), which is linked to anemia [7].
Additionally, the study found that higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, ASAT, GGT, ALP, TIBC, and LD were associated with a greater likelihood of becoming a centenarian [8].
The number of centenarians has been roughly doubling every 10 years since the 1970s [9]. The differences in biomarker values, such as uric acid and creatinine, more than a decade before death suggest a potential link between metabolic health, nutrition, and exceptional longevity [10].
As of a 2022 estimate by the United Nations (UN), there are 593,000 centenarians living in the world [11]. The UN projects there will be 3.7 million centenarians alive by 2050 [12].
CoQ10, a compound that supports metabolic health, has also been found to help maintain healthy creatinine levels and may support insulin sensitivity [13]. Adding a CoQ10 supplement to your regimen could help keep creatinine levels low.
For a detailed list of the specific biomarkers identified by the AMORIS study, consulting the full original AMORIS cohort paper on longevity would be necessary. The study found that liver function biomarkers included alanine aminotransferase (Alat), aspartate aminotransferase (Asat), gamma-glutamyl transferase (GGT), alkaline phosphae (ALP), and lactate dehydrogenase (LD) [14].
References: [1] https://www.instagram.com/reel/Cf0eUxUApJL/ [2] https://www.nature.com/articles/s41598-022-07666-3 [3] https://www.youtube.com/watch?v=cGJC_2Zyh7w [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754859/ [5] https://www.healthline.com/nutrition/how-to-lower-uric-acid [6] https://www.nature.com/articles/s41598-022-07666-3 [7] https://www.nature.com/articles/s41598-022-07666-3 [8] https://www.nature.com/articles/s41598-022-07666-3 [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754859/ [10] https://www.nature.com/articles/s41598-022-07666-3 [11] https://www.un.org/development/desa/dspd/en/population/ageing/ageing-and-development/world-population-ageing-prospects-2022.html [12] https://www.un.org/development/desa/dspd/en/population/ageing/ageing-and-development/world-population-ageing-prospects-2022.html [13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818955/ [14] https://www.nature.com/articles/s41598-022-07666-3
- The groundbreaking AMORIS study connected specific blood biomarker profiles to exceptional brain health and wellness in individuals who reached the age of 100, showcasing the potential influence of metabolic health, nutrition, and medical-conditions on chronic diseases and health-and-wellness throughout aging.
- One significant finding in the study was the association between uric acid levels and longevity; people with lower uric acid levels had a higher chance of reaching 100 years, emphasizing the importance of nutrition and reducing the consumption of red meat, seafood, alcohol, and sugary sodas for maintaining optimal brain health and wellness.
- The research highlighted blood biomarkers related to inflammation, metabolism, liver and kidney function, potential malnutrition, and anemia, pointing to the significance of nutrition and medical-conditions in the health-and-wellness of aging individuals and their association with chronic diseases and longevity.
- In addition to uric acid, the study focused on biomarkers such as total cholesterol, glucose, creatinine, ASAT, GGT, ALP, TIBC, and LD, demonstrating a connection between each of these markers and the likelihood of developing chronic diseases and reaching exceptional longevity.
