Voranigo: A Targeted Therapy for Certain Brain Tumors 🎉
Cost, effects, application, dosage details, and further information on Voranigo medication.
brass tacks: Voranigo is a brand-name pill prescribed for specific types of brain tumors called astrocytomas and oligodendrogliomas. This dirt doesn't have a generic version yet.
The FDA's Verdict 💪
The Food and Drug Administration (FDA) gave the green light to Voranigo to treat grade 2 brain tumors in adults and kids aged 12+. This medication is indeed a game-changer for those with these tumors in certain situations. Dive into the "Uses of Voranigo" section to learn when it's the right choice.
Drug Details 🔬
- Drug Class: Voranigo belongs to a group of drugs known as isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitors, which are a form of targeted cancer therapy.
- Generic Available?: As of now, only the brand version exists.
- Prescription Required?: Yes, you'll need a doctor's prescription.
- Controlled Substance?: Nope, it's not a controlled substance.
Beware of Online Scams! 🚫
Got a friend trying to sell you generic Voranigo online? Beware! As of the latest updates in May 2025, no generic form of Voranigo is available in the United States. Stick to legitimate pharmacies and consult your healthcare provider if you're unsure about purchasing online.
Voranigo Costs and Coupons 💸
Voranigo costs can vary depending on your insurance, location, and the pharmacy you use. Yup, it's a bummer, but that's how it goes with prescription meds.
Luckily, help is at hand! The ServierONE program offers financial assistance for people who need help paying for Voranigo or require help understanding their insurance coverage. Call 800-813-5905 or visit www.servierone.com to learn more and see if you qualify for copay cards and other assistance.
Voranigo Side Effects 😷
This pill can cause some mild to serious side effects. Here's a non-exhaustive list of the most common ones:
- Fatigue
- Headache
- Nausea
- Diarrhea
- Constipation
- Reduced appetite
- Muscle or joint pain/stiffness
- COVID-19 (Yeah, seriously)
- Decreased white blood cell count
- Liver enzyme increases
Don't freak out if you start experiencing these side effects. They might go away in a few days to a couple of weeks. But if they become severe or persistent, chat with your doctor or pharmacist for advice.
Severe Side Effects 🚨
Serious side effects from Voranigo are uncommon, but they can occur. Here are some potential severe side effects and their symptoms to watch out for:
- Liver problems:
- Pain in the upper right abdomen
- Loss of appetite
- Severe tiredness or weakness
- Dark urine
- Jaundice
- Seizures
Wanna report a side effect to the FDA? Swing by MedWatch or dial 800-FDA-1088 if you've experienced any side effects with Voranigo. You'll help make medications safer for everyone!
Uses of Voranigo 🚀
Voranigo for certain brain tumors 🧛♂️
less than 40 kg (about 88 pounds [lb])
Voranigo is used to treat grade 2 astrocytomas and oligodendrogliomas with a specific genetic mutation (an abnormal change in a gene) called IDH1 or IDH2. These brain tumors belong to a group called gliomas and form slowly, often causing symptoms such as headaches, vision and hearing problems, balance issues, weakness on one side of the body, changes in personality or behavior, seizures, and more serious issues.
Voranigo is prescribed after a biopsy or surgery to remove all or part of the tumor. It works by inhibiting abnormal IDH1 and IDH2 enzymes in brain tumor cells, leading to slower tumor growth and preventing the brain tumor from getting worse. Voranigo is approved for use in children 12+ who have these types of brain tumors with the same genetic mutation.
Voranigo and Children 👶
Voranigo is approved for use in children ages 12+ with grade 2 astrocytomas and oligodendrogliomas with IDH1 or IDH2 mutations.
20 mg once per day
Voranigo hasn't been studied in children younger than 12 years old, and its safety and effectiveness in this age group have not been established.
Voranigo Dosage 📊
Voranigo comes in tablet form in two strengths: 10mg and 40mg. The dosage recommended for adults is 40mg once per day. But factors like age, body weight, and side effects may affect the dosage your doctor prescribes.
For kids ages 12+, the dosage depends on their weight, as shown in the table below:
Things to Remember When Taking Voranigo 📝
- Take Voranigo once per day, around the same time each day, to help keep a steady level of the drug in your body.
- If you miss a dose:
- If it's been 6 hours or less since the dose was due, take it as soon as possible and then take your next dose at the usual time.
- If it's been more than 6 hours since the dose was due, skip the missed dose and take your next dose at the usual time.
- You can take Voranigo with or without food.
- Don't crush, split, or chew the tablets – swallow them whole with a glass of water.
- Voranigo is meant for long-term treatment if your doctor determines that it's safe and effective for you.
Voranigo Interactions 🮥
40 kg or more
Voranigo can interact with several other medications, vitamins, herbs, and supplements, so consult your doctor and pharmacist before taking Voranigo.
Here are examples of medications that may interact with Voranigo:
- Ciprofloxacin (Cipro)
- Cyclosporine (Neoral, others)
- Fluvoxamine (Luvox)
- Phenytoin (Dilantin, Phenytek)
- Rifampin (Rifadin, Rimatane)
- Hormonal forms of birth control, such as the combined pill, minipill, or patch
Alcohol Interaction 🍸
40 mg once per day
Drinking alcohol while taking Voranigo may cause some similar side effects, such as headache, nausea, diarrhea, and potentially liver problems, so it's best to avoid booze during Voranigo treatment. Chat with your doctor or pharmacist if you have questions about drinking alcohol while taking Voranigo.
Alternatives to Voranigo 💼
Other treatments for brain tumors are available, and your doctor can help you find an alternative that works best for you. Some options include:
- Chemotherapy with drugs such as the PCV combination regimen (procarbazine, lomustine [CCNU], and vincristine) and temozolomide
- Radiation therapy
Voranigo and Pregnancy, Fertility, and Breastfeeding 🤰
Voranigo and Pregnancy
Voranigo can cause fetal harm and should not be taken during pregnancy unless absolutely necessary. Consult your doctor about alternative treatment options if you're pregnant or planning to become pregnant.
Voranigo and Fertility
Voranigo can affect both male and female fertility, so if you plan to have children in the future, discuss your options with your doctor before starting Voranigo treatment.
Voranigo and Birth Control
If you can become pregnant and are taking Voranigo, you should use a nonhormonal form of birth control, like condoms, while taking Voranigo and for three months after your last dose. Voranigo can reduce the effectiveness of some forms of hormonal birth control.
Voranigo and Breastfeeding
Voranigo should not be taken while breastfeeding. Consult your doctor about alternative feeding options if you're currently breastfeeding or plan to do so in the future.
Note: In this article, we use the terms "female" and "male" to refer to someone's sex assigned at birth. For more information, see this article about the difference between sex and gender.
How Voranigo Works 🧪
Voranigo is approved to treat grade 2 astrocytomas and oligodendrogliomas that have a mutation in the gene for isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2). When the gene for these enzymes is mutated, they don't work correctly, leading to the production of molecules that help the tumor cells grow. Voranigo works by blocking the action of the abnormal IDH1 and IDH2 enzymes in brain tumor cells, leading to slower tumor growth and preventing the brain tumor from getting worse.
• ciprofloxacin (Cipro)• cyclosporine (Neoral, others)• fluvoxamine (Luvox)• phenytoin (Dilantin, Phenytek)• rifampin (Rifadin, Rimatane)• hormonal forms of birth control, such as the combined pill, minipill, or patch
- Voranigo is a targeted cancer therapy, specifically an isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitor, used for certain brain tumors, namely astrocytomas and oligodendrogliomas, in some medical-conditions known as gliomas.
- This medication, approved by the Food and Drug Administration (FDA) to treat grade 2 brain tumors in adults and children aged 12+ in certain situations, belongs to a group of drugs called targeted cancer therapies for brain tumors with specific genetic mutations (IDH1 or IDH2).
- Although Voranigo is a game-changer for those with specific brain tumors, it's crucial to remember that only the brand version exists as of now, with no generic form available in the United States.
- Although there are other treatments for brain tumors, Voranigo, a health-and-wellness option, is beneficial for those with qualifying brain tumors with IDH1 or IDH2 mutations.
- To avoid potential severe side effects like liver problems and seizures when taking Voranigo, it's essential to follow your healthcare provider's recommendations, seek medical advice for any side effects, and use non-hormonal birth control while on treatment and for three months after the last dose.
