New Migraine Drugs: CGRP Antagonists Offer Relief and Prevention
Migraine, a debilitating condition marked by severe headaches and associated symptoms, can be managed with various medications. These include triptans, NSAIDs, and the newer CGRP receptor antagonists, or 'gepants'.
Migraine attacks can be acute and incapacitating, often accompanied by nausea, vomiting, and sensitivity to light and sound. Acute medications, such as triptans (Sumatriptan, Eletriptan, Rizatriptan) and NSAIDs like Naproxen and Celecoxib, are taken at the onset of symptoms to relieve pain, reduce severity, or prevent progression. The newest class, CGRP antagonists like Rimegepant, targets a protein involved in migraine pain and is effective for both treating and preventing episodes.
Preventive medications, like pills, injections, or nasal sprays, reduce the frequency and severity of migraine attacks. Some people may require a combination of acute and preventive treatments. Overuse of acute medications, more than 10 days per month, can lead to medication overuse headaches. Ergotamines, though less commonly prescribed due to potential side effects, can still be used for frequent or long-lasting attacks. Pain relievers and NSAIDs may also help, but long-term NSAID use can have serious side effects.
While there is no cure for migraine, a range of medications can provide relief and improve quality of life. These include triptans, NSAIDs, and the newest class, CGRP antagonists. It's crucial to use these medications wisely, as overuse can lead to further headaches. Consulting a healthcare provider can help determine the best treatment plan for each individual.
